- Title
- A systematic review and quality assessment of economic evaluations of kidney replacement therapies in end-stage kidney disease
- Creator
- Nyokabi, Patricia; Youngkong, Sitaporn; Bagepally, Bhavani Shankara; Okech, Tabitha; Chaikledkaew, Usa; McKay, Gareth J.; Attia, John; Thakkinstian, Ammarin
- Relation
- Scientific Reports Vol. 14, no. 23018
- Publisher Link
- http://dx.doi.org/10.1038/s41598-024-73735-8
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2024
- Description
- End-stage kidney disease (ESKD) is fatal without treatment by kidney replacement therapies (KRTs). However, access to these treatment modalities can be problematic given the high costs. This systematic review (SR) aims to provide an updated economic evaluation of pairwise comparisons of KRTs and the implications for the proportion of patients with access to the KRT modalities, i.e., kidney transplantation (KT), hemodialysis (HD), and peritoneal dialysis (PD). This SR was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020. We searched studies in PubMed, Embase, Scopus, and Cost Effectiveness Analysis (CEA) registry, from inception to March 2023. Thirteen studies were included with pairwise comparisons among three KRTs, with varying proportions of patients for each modality. Seven studies were from high-income countries, including five from Europe. Summary findings are presented on a cost-effectiveness plane and incremental net benefit (INB). KT was the most cost-effective intervention across the pairwise comparisons. KT and PD were both more cost-effective alternatives to HD. HD was more costly and less effective than PD in all studies except one. Concurrent efforts to increase both KT and PD represented the best scenario to improve treatment options for ESKD patients.
- Subject
- end stage kidney disease; kidney replacement therapies; economic evaluation; systematic review; SDG 3; Sustainable Development Goal
- Identifier
- http://hdl.handle.net/1959.13/1513510
- Identifier
- uon:56741
- Identifier
- ISSN:2045-2322
- Rights
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
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